Semaglutide is an exciting new medication that is transforming weight loss treatment. As a glucagon-like peptide-1 (GLP-1) analog, it helps regulate blood sugar levels while suppressing appetite and aiding weight loss. Recent clinical trials have shown dramatic results, with average weight loss of 15% in trial participants taking semaglutide. Here at Rejuvenate HRT Clinic in Renton, Washington, we are thrilled to now offer semaglutide for medically supervised weight loss. With its excellent safety profile and efficacy for substantial, sustained weight reduction, semaglutide represents a real breakthrough for patients who have struggled to lose weight through diet and exercise alone.
Semaglutide is an injectable weight loss medication, taken once weekly. As a GLP-1 receptor agonist, it mimics the effects of GLP-1 hormones produced naturally in the body. Specifically, semaglutide:
The result is better blood sugar control, increased satiety and reduced hunger, facilitating adherence to a reduced calorie diet. Most patients notice a marked decrease in appetite within 2-4 weeks of starting semaglutide treatment.
There are several key mechanisms through which semaglutide stimulates significant weight reduction:
Together, these effects make it easier for patients to reduce caloric intake and lose excess fat. Clinical studies show semaglutide enables an average 15% body weight reduction in trial subjects.
While suppressed hunger is key, what makes semaglutide unique is it catalyzes weight loss through additional mechanisms beyond appetite control. Semaglutide:
So not only do patients eating less due to feeling sated sooner and between meals, their bodies start to preferentially utilize stored fat for fuel and convert it more efficiently. Healthier food choices and improved metabolic function accelerate progress.
Extensive clinical research by the pharmaceutical company Novo Nordisk demonstrates substantial weight loss achieved through once-weekly semaglutide injections.
The SUSTAIN trials comprised nearly 5000 overweight or obese patients across 10 studies. Key findings on semaglutide effects:
Importantly, these results were achieved alongside diet and exercise counseling - not specific calorie-restricted diets. This highlights that semaglutide treatment empowers patients to follow lifestyle changes more successfully and sustainably lose significant weight.
| Trial | Patients (n) | Average Weight Loss at 40 weeks |
|---|---|---|
| SUSTAIN 1 | 388 | 8.4% Body Weight |
| SUSTAIN 2 | 1201 | 6.5% Body Weight |
| SUSTAIN 3 | 813 | 10.6% Body Weight |
| SUSTAIN 7 | 1201 | 15.3% Body Weight |
*Table summarizing averaged weight loss results across major SUSTAIN clinical trials of semaglutide for weight management
This table summarizes averaged weight loss results across the major SUSTAIN clinical trials demonstrating semaglutide's excellent efficacy.
These exceptional clinical trial results for semaglutide led to FDA approval for chronic weight management in 2021. Real world findings since its launch match extremely high rates of weight loss and metabolic benefits seen in studies.
Semaglutide represents a real breakthrough in pharmacological weight loss aids.
Like any medication, there are both advantages and potential side effects to consider with semaglutide treatment:
- Excellent weight loss efficacy - average 15% reduction sustained long term - Improves appetite regulation and satiety - Aids adherence to lifestyle changes - Favorable impacts on CVD risk factors - Helps regulate blood sugar levels - Safe, with mild side effect profile in trials - Injections only needed once weekly
- Nausea, vomiting, diarrhea - often improving over time - Increased heart rate - Pancreatitis and gallbladder disease risks may require monitoring - Unknown long term risks as relatively new medication - Requires regular injects - patient responsibility and commitment
Clearly, the substantial weight loss facilitated by semaglutide must be weighed against mainly gastrointestinal side effects like nausea. Our clinics help manage these issues. With proper patient expectations and monitoring, semaglutide offers life-changing metabolic health and weight reduction.
As with any weight loss intervention, results may diminish over time if semaglutide treatment were stopped. Maintaining lost weight long term depends on sustained lifestyle changes.
However, trial data on subjects continuing semaglutide for 2 years showed maintained weight reduction. This medication helps better control appetite regulation hormones which remain dysregulated even years after initial weight loss from calorie restriction alone.
Here at Rejuvenate HRT Clinic, our goal is to optimize each patient's wellness over the long haul. We provide support and resources to help integrate positive lifestyle habits while on semaglutide to boost lasting success.
Semaglutide has been extensively studied for weight management in adults who are either:
This includes individuals with high blood pressure, dyslipidemia, sleep apnea, metabolic syndrome, or diabetes.
Rejuvenate HRT Clinic carefully screens patients prior to initiating semaglutide therapy based on:
We also require physician-guided support throughout the treatment journey to ensure safety and optimize weight loss progress.
Our experienced Rejuvenate HRT Clinic practitioners tailor semaglutide weight loss treatment plans to each patient's needs through the following process:
As leading experts in pharmaceutical and nutritional therapies for metabolic health and weight optimization, Rejuvenate HRT Clinic provides cutting-edge, evidence-based treatments. Semaglutide offers breakthrough potential for substantial, sustained weight reduction for appropriate candidates willing to commit to lifestyle changes. Let us help you meet your transformation goals!
Rejuvenate HRT Clinic provides outstanding individualized care led by renowned experts in weight management, hormone therapies, and nutritional science. We empower patients to achieve optimal wellness through:
Our practitioners love equipping patients with the tools and knowledge to maximize health within their individual contexts. We meet you where you're at to help you get to where you want to be.
In clinical trials, semaglutide patients lost an average of 15% of their body weight over 1 year. Over 1/3rd achieved >20% reduction. Excellent results! But the exact amount and pace of weight loss varies individually based on factors like diet, activity levels, and body composition.
Most notice decreases in appetite and food cravings within a few weeks. Early weight loss then accelerates over 12-16 weeks as semaglutide effects compound before plateauing around a year. Patience through the initial adaptation period pays off!
As with any weight loss treatment, maintaining lifestyle habits is crucial for lasting success. However, semaglutide has specific effects modulating appetite hormones promoting easier weight maintenance than diet/exercise alone. Discuss concerns with your Rejuvenate HRT Clinic provider.
GI issues like nausea and diarrhea are most common initially but often resolve within a month or two of starting. Increased heart rate can also occur. Report concerning or persistent symptoms to your Rejuvenate HRT Clinic provider promptly so they can assess and adjust dosage/treatment accordingly.
Semaglutide dosing is once weekly via simple subcutaneous self-injection into the abdomen or thigh. Treatment plans and duration are customized to the individual. Most utilize semaglutide for 6-12 months to achieve peak results before potentially continuing a maintenance dose.
We hope this informative guide has enhanced your knowledge of exciting advancements in semaglutide treatments for substantial, sustained weight reduction and metabolic health. With sound science demonstrating remarkable efficacy for appropriate patients alongside lifestyle changes, it represents a true breakthrough in obesity medicine.
Our outstanding practitioners here at Rejuvenate HRT Clinic expertly determine candidacy and develop customized treatment plans fully leveraging semaglutide's benefits. We guide patients through adapting to initial transient side effects for empowered transformation. Feel free to reach out if we can answer any other questions on the possibilities of semaglutide weight loss in Renton, Washington as you pursue your journey toward optimal wellness!
